Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.   We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.   GRAIL is headquartered in the bay area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.   For more information, please visit grail.com The Clinical Laboratory Technologist VI performs highly advanced laboratory procedures that support clinical and pre-clinical exploratory safety studies in accordance with established protocols and quality standards. The role contributes to the execution, evaluation, and documentation of complex assays, the preparation and handling of specialized specimens and materials, and the consistent application of laboratory methods. The position provides experienced technical support across laboratory workflows to promote accuracy, reliability, and compliance within the Clinical Laboratory Technologist job family. This position works on the 2nd shift, Wed thru Sat, 1:30pm - 12:00am and is on-site full-time at our office located in Durham, NC RESPONSIBILITIES: Perform highly advanced laboratory testing procedures in alignment with established laboratory methods, study protocols, and quality requirements to support clinical research and safety study objectives. Prepare and handle complex or specialized samples, reagents, and materials by following detailed workflows that ensure accurate labeling, tracking, and compliance with defined handling requirements. Operate and maintain laboratory instruments and analytical systems by performing routine and advanced checks, calibrations, and troubleshooting steps, and reporting equipment issues to assigned personnel for follow-up. Record, review, and verify test data in laboratory systems with accuracy, consistency, and adherence to defined documentation and data integrity standards. Review assay and quality control results, identify expected and unexpected patterns, and escalate observations requiring additional analysis by senior laboratory staff. Perform quality control activities by running controls, documenting deviations, and contributing to the review of quality trends under established laboratory quality expectations. Support coordination of study activities by monitoring workflow needs, confirming the availability of materials and equipment, and completing required documentation according to defined timelines. Participate in verification or qualification activities related to equipment, methods, or reagent lots by following established procedures and performing assigned tasks with precision. Contribute to workflow refinement by identifying routine inefficiencies or procedural questions and communicating observations to senior laboratory personnel to support process clarity and consistency. Maintain a clean, organized, and compliant laboratory workspace by adhering to required safety, biosafety, and housekeeping practices to support ongoing regulatory readiness. These responsibilities summarize the role’s primary responsibilities and are not an exhaustive list. They may change at the company’s discretion. REQUIRED QUALIFICATIONS: Bachelor’s in MLS or related field; Master’s preferred. 1+ years experience in high-complexity molecular diagnostics or equivalent. Advanced ASCP or specialist certification strongly preferred. Demonstrated level of knowledge regarding applicable regulatory standards commensurate with the position's complexity and scope, contributing to organizational regulatory compliance. Minimal applicable standards for this position include:  Clinical laboratory regulations (e.g. CAP, CLIA, NYSDOH, ISO 15189) Operations within the regulated medical device environment (e.g. IVDD, IVDR, FDA 21 CFR 800 series, FDA 21 CFR Part 11) Development and Operations within a regulated clinical study environment (e.g.  ICH E6 (GCP), ISO 20916, FDA 21 CFR Part 11, Part 50, Part 54, Part 56) PREFERRED QUALIFICATIONS: Expert-level molecular diagnostics knowledge. Leadership in cross-departmental initiatives and change management. Exceptional communication for technical and non-technical audiences. Ability to design, execute, and document method validations to regulatory standards. PHYSICAL DEMANDS AND WORKING ENVIRONMENT: Operate in a CLIA- and CAP-accredited clinical laboratory with routine exposure to biohazardous materials and chemicals, requiring full PPE and biosafety compliance. Physically active environment with prolonged standing, repetitive tasks, and frequent instrument interaction. Ability to lift reagents or supplies (~25–30 lbs) occasionally. Flexible scheduling needed to support GRAIL’s testing operations—including early/late shifts and potential weekend/on-call coverage. Occasional travel may be required for training, labs benchmarking, or cross-site support. The expected, full-time, annual base pay scale for this position is $28.36 - $48.07. Actual base pay will consider skills, experience, and location. This role may be eligible for other forms of compensation, including an annual bonus and/or incentives, subject to the terms of the applicable plans and Company discretion. This range reflects a good-faith estimate of the range that the Company reasonably expects to pay for the position upon hire; the actual compensation offered may vary depending on factors such as the candidate’s qualifications. Employees in this role are also eligible for GRAIL’s comprehensive and competitive benefits package, offered in accordance with our applicable plans and policies. This package currently includes flexible time-off or vacation; a 401(k) retirement plan with employer match; medical, dental, and vision coverage; and carefully selected mindfulness programs.   GRAIL is an equal employment opportunity employer, and we are committed to building a workplace where every individual can thrive, contribute, and grow. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, gender, gender identity, sexual orientation, age, disability, status as a protected veteran, , or any other class or characteristic protected by applicable federal, state, and local laws. Additionally, GRAIL will consider for employment qualified applicants with arrest and conviction records in a manner consistent with applicable law and provide reasonable accommodations to qualified individuals with disabilities. Please contact us at rc@grailbio.com if you require an accommodation to apply for an open position.   GRAIL maintains a drug-free workplace. We welcome job-seekers from all backgrounds to join us!