Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity Reporting into the Vice President, Marketing, the Senior Director, Thought Leader Liaison Lead is a highly visible National leadership role responsible for building and executing Amylyx’s commercial thought leader engagement and regional marketing capability from the ground up. The Senior Director will establish the TLL function, hire and develop a field-based team, and serve as the strategic owner of Commercial KOL identification, segmentation, and engagement. This highly cross-functional role partners closely with Marketing, Medical Affairs, Sales, Compliance, and Executive Leadership to ensure commercial thought leader engagement is compliant, insight-driven, and aligned to strategy.  **We anticipate hiring the Senior Director, Thought Leader Liaison Lead role in September 2026** Responsibilities * Build, hire, and develop a field-based TLL team, establishing the infrastructure, processes, and culture needed to stand up this capability effectively * Define and execute the TLL strategic plan, including KOL identification and segmentation, key account engagement, and peer-to-peer programming based on educational needs * Develop and maintain a robust KOL mapping and tiering framework to ensure optimal engagement of national, regional, and local thought leaders across relevant specialties based on expertise, scientific leadership, educational needs. * Oversee the planning and execution of advisory boards, speaker bureau programs, and congress engagements * Oversee regional marketing efforts ensuring consistent execution of brand strategy and messaging across geographies, while adapting engagement approaches to local market dynamics and key account priorities * Build and maintain systems for capturing and synthesizing KOL and field-based insights to inform internal strategy * Establish and monitor performance metrics and MBOs to measure TLL team effectiveness and drive continuous improvement * Partner with Marketing to align TLL field engagement with brand strategy, messaging, commercial priorities, and inform omnichannel optimization * Partner with Medical Affairs and Regional Scientific Director leadership to ensure compliant collaboration and clear delineation of commercial and medical engagement * Ensure all commercial thought leader engagement activities are executed in full compliance with regulatory, legal, and company guidelines. Required Qualifications * Bachelor's degree  * 12+ years of experience in pharmaceutical or biotechnology commercial roles, including significant experience in thought leader engagement, sales, or marketing leadership with a minimum of 5 years leading thought leader engagement activities, strategy, and field-based teams. * Deep understanding of KOL engagement best practices, compliance requirements, and the intersection of commercial and medical strategy. * Exceptional communication, relationship-building, and cross-functional leadership skills. * High degree of initiative and comfort operating in a fast-paced, mission-driven environment with a bias for building * Demonstrated success building and leading customer-facing field-based teams in rare disease, specialty, or complex launch environments. * Willingness to travel approximately 50% of the time to support field team leadership and customer engagement activities, including overnight and occasional weekend travel. Preferred Requirements * Advanced degree (MBA, PharmD, or equivalent) * Endocrinology experience Work Location and Conditions * At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee. * You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. * You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity. Estimated Pay Range $248,000—$279,000 USD To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.